Muhammad Akram Shahzad Khokhar
School of Pain and Regenerative Medicine (SPRM), The University of Lahore, PakistanPublications
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Research
Molecular insights into phytochemical-protein interactions: A paradigm shift in breast cancer therapy
Author(s): Muhammad Akram Shahzad Khokhar, Malik Ihsan Ullah Khan, Arif Malik*, Gul Zaib, Haleema Saadia and Qurban Ali
Breast cancer is among the most common cancers, and for cancer treatment, it calls for fresh strategies. Flavonoids as phytochemicals are natural bioactive compounds showing luminous prospects as anti-cancer given their specific action against proteins. The current work focuses on the impact of phytochemicals on proteins related to breast cancer as a new approach to therapy. The study looks at the performance of phytochemicals including CBD (Cannabidiol), THC (Tetrahydrocannabinol), and EGCG (Epigallocatechin-3-Gallate) concerning conventional chemotherapy drugs including paclitaxel and zoledronic acid. AutoDock Vina was used to predict the binding energy of phytochemicals and standard drugs to the target proteins in BCa progression, including HER2 (Human Epidermal Growth Factor Receptor 2), ER (Endoplasmic Reticulum), VEGF (Vascular Endothelial Growth Factor), etc. Pharmacokinetic pr.. Read More»
DOI: 10.5281/zenodo.18348956