Muhammad Akram Shahzad Khokhar

Department of Pain and Regenerative Medicine (PRM), The University of Lahore, Lahore, Pakistan

Publications

• Research Article   
  Exploring phytochemical interventions targeting Cyclin-D, MELK, and LUZP in triple-negative breast cancer: In-vitro and in-silico approach
  Author(s): Muhammad Akram Shahzad Khokhar, Malik Ihsan Ullah Khan, Arif Malik*, Haleema Saadia, Gul Zaib and Qurban Ali
  
  Triple-Negative Breast Cancer (TNBC) is an invasive breast cancer without estrogen progesterone receptors and HER-2 overexpression. This subtype usually results in poor prognosis and has limited management. Cyclin-D, MELK, and LUZP are important proteins in cell cycle regulation, cell survival, and metastasis. Therefore, it can be postulated that going for phytochemical intervention on these proteins may offer an opportunity for TNBC management. Specifically, this study aims to examine and compare potential phytochemicals and the binding interactions in an in-vitro and in-vivo TNB rat model in terms of Cyclin-D, MELK (Maternal Embryonic Leucine Zipper Kinase), and LUZP (Leucine Zipper Protein) expression levels, and toxicity. Molecular docking analysis was performed to evaluate the binding affinity of phytochemical compounds against Cyclin-D, MELK, and LUZP. The binding interactions a.. Read More»
  DOI: 10.5281/zenodo.17985031

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