Zahid Iqbal
Department of Zoology, Government College University, Faisalabad, PakistanPublications
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Research Article
Protective mechanisms of Azadirachta indica against titanium dioxide nanoparticle-induced reproductive toxicity through antioxidant and endocrine axis regulation
Author(s): Muhammad Asif Latif*, Farhat Jabeen, Adeel Khalid, Zahid Iqbal, Muhammad Tayyab and Muhammad Imran
Aim: This study investigated the protective effects of Azadirachta indica (Neem) against Titanium Dioxide Nanoparticles (TiO2-NPs)-induced reproductive toxicity in male Sprague Dawley rats. Materials and Methods: A. indica leaves were extracted in methanol and the LC50 was determined (‘2155.21 mg/kg’ BW). Rats were divided into six groups with eight rats in each group (n=8), including a control group, saline group, positive group (TiO2-NPs, ‘120 mg/kg’ BW) and treatment groups receiving additional low (‘100 mg/kg’), medium (‘150 mg/kg’), or high (‘300 mg/kg’) doses of neem extract for ‘90 days’. Results: TiO2-NPs significantly reduced body weight, testicular somatic index and hormone levels a.. Read More»